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ID 113349
タイトル別表記
メタボリックシンドロームモデルマウス、TSODマウスにおいて、日常的なコーヒー摂取は膵臓β細胞へのダメージ及び非アルコール性脂肪肝を抑制する
EFFECTS OF COFFEE INTAKE ON METABOLIC SYNDROME
著者
渡邉, 俊介 徳島大学大学院医科学教育部(医学専攻)
Baba, Hayato Tokushima University
Morimoto, Yuki Tokushima University
キーワード
animal model
beta cell failure
coffee intake
hepatocellular carcinoma
nonalcoholic steatohepatitis
資料タイプ
学位論文
抄録
Background: Metabolic syndrome is one of the most important health issues worldwide. Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout the body. The liver phenotype, which is called nonalcoholic steatohepatitis (NASH), frequently progresses to hepatocellular carcinoma. We recently established a new animal model, Tsumura-Suzuki obese diabetic (TSOD) mice, which spontaneously exhibit obesity, diabetes, hyperlipidemia, and NASH with liver nodules.
Methods: We examined the effects of coffee intake on various conditions of the metabolic syndrome using TSOD mice. The daily volume of coffee administered was limited so that it reflected the appropriate quantities consumed in humans. To clarify the effects of the specific components, animals were divided into two coffee-intake groups that included with and without caffeine.
Results: Coffee intake did not significantly affect obesity and hyperlipidemia in TSOD mice. In contrast, coffee intake caused various degrees of improvement in the pancreatic beta cell damage and steatohepatitis with liver carcinogenesis. Most of the effects were believed to be caused by a synergistic effect of caffeine with other components such as polyphenols. However, the antifibrotic effects of coffee appeared to be due to the polyphenols rather than the caffeine.
Conclusions: A daily habit of drinking coffee could possibly play a role in the prevention of metabolic syndrome.
掲載誌名
Metabolic Syndrome and Related Disorders
ISSN
15404196
15578518
cat書誌ID
AA11853678
AA12814809
出版者
Mary Ann Liebert, Inc.
15
4
開始ページ
170
終了ページ
177
発行日
2017-05-01
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Syunsuke Watanabeの学位論文として提出され,学位審査・授与の対象となっている。
Final publication is available from Mary Ann Liebert, Inc., publishers https://doi.org/10.1089/met.2016.0114
権利情報
© 2017, Mary Ann Liebert, Inc.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3265号
学位記番号
甲医第1414号
学位授与年月日
2019-03-19
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院