| ID | 111340 |
| 著者 |
Purwanti, Nunuk
The University of Tokushima|Gadjah Mada University
Azlina, Ahmad
The University of Tokushima
Karabasil, Mileva R
The University of Tokushima|Belgrade University
|
| キーワード | submandibular gland
IL-6
STAT3
duct-ligation
|
| 資料タイプ |
学術雑誌論文
|
| 抄録 | Ligation of the main excretory duct (MED) of the mouse submandibular gland (SMG) induced the expression of Sca-1, a stem cell marker. Sca-1 expression increased prominently in almost all of cells in the duct system, except the acinar cells. Sca-1 induction was accompanied with phosphorylated-STAT3 (Y705) elevation, which was localized in the nuclei of all duct cells. Electrophoretic mobility shift assay (EMSA) confirmed the specific binding of STAT3 to the GAS sequence, a biding site of gamma interferon activating site. Present study suggested one of the initial steps of the tissue regeneration after injury includes STAT3 pathway.
|
| 掲載誌名 |
The Journal of Medical Investigation
|
| ISSN | 13496867
13431420
|
| cat書誌ID | AA11166929
AA12022913
|
| 出版者 | Faculty of Medicine Tokushima University
|
| 巻 | 56
|
| 号 | Supplement
|
| 開始ページ | 253
|
| 終了ページ | 254
|
| 並び順 | 253
|
| 発行日 | 2009-12
|
| EDB ID | |
| 出版社版DOI | |
| 出版社版URL | |
| フルテキストファイル | |
| 言語 |
eng
|
| 著者版フラグ |
出版社版
|
| 部局 |
歯学系
生物資源系
|
