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ID 114814
タイトル別表記
Past infections and low ACPA in RA
著者
Kanamori, Minaho The University of Tokushima
Nagase, Yutaro The University of Tokushima
河南, 真吾 The University of Tokushima
川人, 圭祐 Kaifu Tokushima Prefectural Hospital 徳島大学 教育研究者総覧
稲葉, 香織 Tokushima Prefectural Central Hospital 徳島大学 教育研究者総覧
Miyatake, Akiko Yamakami Hospital
近藤, 啓介 The University of Tokushima
田畑, 良 The University of Tokushima KAKEN研究者をさがす
鈴記, 好博 The University of Tokushima
キーワード
rheumatoid arthritis
ACPA
environmental factor
infection
bacteria
資料タイプ
学術雑誌論文
抄録
Background : Rheumatoid arthritis (RA), an autoimmune disease of unknown etiology, is believed to occur as the result of actions of genetic and environmental factors. In this study, we examined the relation of past histories about infectious diseases with the levels anti-citrullinated protein autoantibodies (ACPA) in RA. Methods : Results of a questionnaire about histories of infectious diseases were obtained from 85 patients with RA, and were analyzed. Results : Significantly lower level of ACPA was detected in patients with the history of tonsillitis, otitis media or urinary cystitis than in those without it. There was no difference in the level of ACPA in RA patients between with and without cold / influenza, rubella, chickenpox, herpes labialis or herpes zoster. When RA patients were divided into two groups, high-level and low-level ACPA, multiple logistic regression analysis revealed that the history of otitis media was a significantly independent factor for the low level of ACPA. There was no significant relation between the level of rheumatoid factor and histories of infectious diseases. Conclusion : This study clarified that the past history of otitis media is associated with the low level of ACPA in RA.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA12022913
AA11166929
出版者
Tokushima University Faculty of Medicine
67
1-2
開始ページ
182
終了ページ
188
並び順
182
発行日
2020-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系