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ID 113967
著者
井戸, 佑介 University of Tokushima
Yoshitomi, Tatsuki University of Tokushima
大倉, 一人 Suzuka University of Medical Science
キーワード
Voltage-dependent anion channel (VDAC)
Mitochondria
Pseudogene
Synteny
資料タイプ
学術雑誌論文
抄録
Rodent and human genomes were screened to identify pseudogenes of the type 1 voltage-dependent anion channel (VDAC1) in mitochondria. In addition to the 16 pseudogenes of rat VDAC1 identified in our recent study, 15 and 13 sequences were identified as pseudogenes of VDAC1 in mouse and human genome, respectively; and 4, 2, and 1 sequences, showing lower similarities with the VDAC1 sequence, were identified as “possible pseudogene candidates” in rat, mouse, and human, respectively. No syntenic combination was observed between rodent and human pseudogenes, but 2 and 1 possible pseudogene candidates of VDAC1 of rat and mouse, respectively, were found to have syntenic counterparts in mouse and rat genome, respectively; and these syntenic counterparts were genuine VDAC1 pseudogenes. Therefore, syntenic combinations of pseudogenes of VDAC1 were useful not only for a better understanding of the phylogenetic divergence history of rodents but also for ascertaining possible pseudogene candidates as genuine pseudogenes.
掲載誌名
Genomics
ISSN
08887543
cat書誌ID
AA10678346
AA11537587
出版者
Elsevier
104
2
開始ページ
128
終了ページ
133
発行日
2014-05-22
権利情報
Open Archive
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
先端酵素学研究所