和田, 佑馬 The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
森根, 裕二 The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
居村, 暁 The University of Tokushima KAKEN研究者をさがす
池本, 哲也 The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
齋藤, 裕 The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
髙須, 千絵 The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
山田, 眞一郎 The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
島田, 光生 The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Colorectal liver metastasis
Background: The role of hypoxia-inducible factor-1α (HIF-1α) in primary colorectal cancer (CRC) and colorectal liver metastasis (CRLM) has remained unclear. The aim of this study was to investigate HIF-1α expression and its association with prognosis in patients with CRLM with a focus on hepatic stellate cells (HSCs).
Methods: Colon cancer cells were cultured in HSC-conditioned medium (CM), and HIF-1α expression and cell migration were analyzed. Seventy-five patients with CRLM who underwent an initial curative hepatectomy were enrolled. We examined HIF-1α expressions and patient prognosis between primary CRCs and the matched liver metastatic specimens.
Results: Activated HSCs induced HIF-1α mRNA and protein expression in colon cancer cells (p < 0.01) and promoted cell migration (p < 0.01). The positive rates of HIF-1α expression in primary CRCs and liver metastases were 68.0 and 72.0%, respectively. There were no differences in overall (OS) and disease-free survival (DFS) of HIF-1α expression in primary CRC. However, HIF-1α expression in liver metastasis correlated to poor prognosis in both OS and DFS. Furthermore, patients with HIF-1α positive expression in liver metastasis had poor prognosis.
Conclusion: HIF-1α expression in liver metastasis determines poor prognosis of CRLM patients. HSCs might play a key role in aggressive phenotypes of tumor cells.
World Journal of Surgical Oncology
BioMed Central|Springer Nature
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