Watanabe, Tsutomu The University of Tokushima
Takaue, Yoichi The University of Tokushima
Kawano, Yoshifumi The University of Tokushima
peripheral blood stem cell transplantation
Patients with a number of different malignancies have been treated with high-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT). PBSC already replaced bone marrow as the source of autologous hematopoietic progenitor support. This is due to ease of collection, rapid engraftment and less possibility of tumor cell contamination in the graft. Furthermore, allogeneic transplantation of granulocyte colony-stimulating factor (G-CSF) mobilized PBSC is now being increasingly performed. Recent advance of clinical PBSCT and new strategies are stressed in this review. New strategies include CD 34+cell purification, ex vivo expansion of PBSC and PBSC as a target cell for gene therapy. Major future advance may occur better understanding of the mechanism of mobilization and the biology of PBSC.
The Journal of Medical Investigation
The University of Tokushima School of Medicine
jmi_44_1-2_25.pdf 474 KB