ID 111638
著者
前川, 洋一 The University of Tokushima
Himeno, Kunisuke The University of Tokushima
Katunuma, Nobuhiko Tokushima Bunri University
キーワード
cathepsin B
antigen-processing
Th1/Th2
experimental leishmaniasis
資料タイプ
学術雑誌論文
抄録
BALB/c mice are genetically susceptible to infection with Leishmania major (L. major). When such mice infected with L. major were treated with specific inhibitors of cathepsin B, a lysosomal cysteine protease that digests exogenous antigenic proteins, the mice acquired resistance against L. major infection. T cells from these mice produced large amounts of IFN-γ and low amounts of IL-4 as compared with those of untreated BALB/c mice. In addition, the mice treated with cathepsin B inhibitor produced a high titer of IgG2a specific antibodies and only low titers of IgG1 and IgE antibodies. This type of response is in contrast with the high specific IgG1 or IgE antibody responses which are the usual antibody responses in BALB/c mice infected with L. major. These findings indicate that cathepsin B may be critically involved in processing antigens of L. major to promote exclusively the development of Th2 type CD4+T cell responses.
掲載誌名
The Journal of Medical Investigation
ISSN
13431420
cat書誌ID
AA11166929
出版者
The University of Tokushima School of Medicine
44
1-2
開始ページ
33
終了ページ
39
並び順
33
発行日
1997-08
EDB ID
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版