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ID 83486
著者
Dirican, Melahat Medical Faculty of Uludag University, Department of Biochemistry
Sarandol, Emre Medical Faculty of Uludag University, Department of Biochemistry
Ulukaya, Engin Leeds University, School of Biochemistry and Molecular Biology
Tokullugil, Hatice Asuman Medical Faculty of Uludag University, Department of Biochemistry
キーワード
Lecithin
cholesterol acyltransferase
smoking
lipids
資料タイプ
学術雑誌論文
抄録
Cigarette smoking is one of the major risk factors for cardiovascular disease.The mechanism responsible for this association is still unknown. We measured the activity of lecithin:cholesterol acyltransferase (LCAT), a key factor in the esterification of plasma cholesterol and reverse cholesterol transport, and the levels of lipids and apolipoproteins in the serum of 27 cigarette smoking and 31 non-smoking (control) men. We could not find any significant difference among these parameters between the groups. Serum LCAT activity was lower in smokers, but the difference was statistically nonsignificant. We also classified the two groups in respect to their serum lipid levels as hyper- and normolipidemic, we observed that normolipidemic-smokers had lower (p<0.05) high density lipoprotein-cholesterol (HDL-C) and HDL-ester cholesterol levels compared to the normolipidemic-nonsmokers. While there were no any significant differences between hyperlipidemic-smokers and nonsmokers with respect to any of the parameters.
In the end we have got the idea that smoking seems to affect HDL-C and HDL-ester cholesterol levels in the normolipidemic-smokers group, only, Also, LCAT activity tended to be lower in smokers compared to nonsmokers.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
46
3-4
開始ページ
169
終了ページ
172
並び順
169
発行日
1999
備考
フルテキストファイル
言語
eng