アクセス数 : ?
ダウンロード数 : ?
ID 83622
著者
宮本, 賢一 Department of Nutritional Science, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
イトウ, ミキコ Department of Nutritional Science, The University of Tokushima School of Medicine
瀬川, 博子 Department of Nutritional Science, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
クワハタ, マサシ Department of Nutritional Science, The University of Tokushima School of Medicine
キーワード
parathyroid
phosphate
transporter
secondary hyperparathyroidism
vitamin D
資料タイプ
学術雑誌論文
抄録
Retention of inorganic phosphate (Pi) and associated hyperphosphatemia are important in the development of hyperparathyroidism secondary to renal failure. The beneficial effect of a low-Pi diet in the prevention of hyperparathyroidism can be attributed to the decrease in PTH secretion. This effect of Pi may be mediated by specific molecules in the parathyroid cell membrane. A complementary DNA encoding a Na+-Pi co-transporter, termed rat PiT-1, has been isolated from rat parathyroid. The amount of PiT-1 mRNA in the parathyroid is controlled by vitamin D and dietary Pi, which are the most important regulators of PTH secretion. The parathyroid Pi transporter may mediate the effects of extracellular Pi and PTH secretion in secondary hyperparathyroidism. In this study, we focus on the function of Na/Pi co-transporters in the parathyroid glands as inorganic Pi sensor.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
47
3-4
開始ページ
118
終了ページ
122
並び順
118
発行日
2000
備考
フルテキストファイル
言語
eng
部局
医学系