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ID 83625
著者
サカモト, サダイチ Department of Nutrition, The University of Tokushima School of Medicine
ムトウ, タケシ Department of Nutrition, The University of Tokushima School of Medicine
ヨコタ, マサシ Department of Nutrition, The University of Tokushima School of Medicine
イシムラ, ノリコ Department of Nutrition, The University of Tokushima School of Medicine
ニワ, ヤスハル Department of Nutrition, The University of Tokushima School of Medicine
原田, 永勝 Department of Nutrition, The University of Tokushima School of Medicine KAKEN研究者をさがす
オカダ, カズコ Department of Nutrition, The University of Tokushima School of Medicine
中屋, 豊 Department of Nutrition, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
hyperinsulinemic euglycemic clamp
insulin resistance
dietary fat
training
food restriction
資料タイプ
学術雑誌論文
抄録
High-fat diets induce whole-body insulin resistance. The aim of this study was to compare the effect of two interventions:3-day food restriction (66%of ad libitum fed) and 3-day exercise training (voluntary running wheels), on decreased insulin-mediated whole body glucose uptake in high-fat fed rats (5 mo old) using the hyperinsulinemic euglycemic clamp procedure. The control group was maintained on rat chow alone. After high-fat feeding for2wk, insulin-stimulated whole body glucose utilization was significantly decreased by26%. The exercise training was more effective than food restriction in lowering plasma concentrations of insulin and triacylglycerol and tissue concentrations of triacylglycerol in soleus muscles. Diminished whole-body glucose uptake resulting from high-fat feeding was reversed completely by exercise training, but only partially by food restriction.
The time course of starvation on insulin-stimulated glucose uptake was also observed in high-fat fed rats. Although the extension of starvation time to 48h resulted in decreased plasma glucose, insulin and triacylglycerol concentrations, whole body glucose uptake did not increase further.
These findings suggest that short-term exercise has a higher restorative effect on insulin sensitivity in high-fat fed rats than food restriction, in spite of the same loss in body weight, presumably due in part to improved local lipid availability.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
47
3-4
開始ページ
138
終了ページ
144
並び順
138
発行日
2000
備考
フルテキストファイル
言語
eng
部局
医学系