ID 110672
著者
Yao, Dengfu Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima|Department of Gastroenterology, Affiliated Hospital, Nantong Medical College
桒島, 正道 Department of Laboratory Medicine, The University of Tokushima School of Medicine
木戸, 博 Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
influenza encephalitis
cytokines
nitric oxide synthase
mini-plasmin
資料タイプ
学術雑誌論文
抄録
The pathogenesis of influenza encephalopathy or encephalitis is poorly understood. This review summarizes our recent studies of the roles played by inflammatory cytokines, inducible nitric oxide synthase (iNOS), adhesion molecules and mini-plasmin in influenza encephalitis. After the intranasal infection of newborn mice with the non-neurotropic strain of influenza A virus (IAV) Aichi/2/68/H3N2, encephalitis and severe brain edema were observed within 3-5 days. IAV-RNA and abnormalities in the blood-brain barrier permeability were detected in association with an increase in them RNA expressions of endothelin-1, iNOS, and tumor necrosis factor-α. Furthermore, the accumulation in the brain capillaries of mini-plasmin, which proteolytically induces the viral envelope fusion activity and allows the virus to enter the cells, changes the brain from non-susceptible to susceptible to non-neurotropic IAV multiplication. The accumulation of mini-plasmin was markedly greater in newborn mice with an impaired mitochondrial fatty acid metabolism. These inflammatory mediators and the accumulation of mini-plasmin in the brain may play an important role in the onset and progression of IAV encephalitis.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
50
1-2
開始ページ
1
終了ページ
8
並び順
1
発行日
2003
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
先端酵素学研究所