ID 110708
著者
香美, 祥二 Department of Pediatrics, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
コンドウ, シュウジ Department of Pediatrics, The University of Tokushima School of Medicine
キーワード
β1integrins
Glomerulosclerosis
Focal adhesion kinase (FAK)
Transforming growth factor-β (TGF-β)
Platelet-derived growth factor (PDGF)
Mitogen activated protein kinase (MAPK)
資料タイプ
学術雑誌論文
抄録
The renal glomerulus is composed of three types of glomerular cells (mesangial cell (MC), endothelial cell and podocyte) and extracellular matrix (ECM) consisting of the glomerular basement membrane (GBM) and mesangial matrix. It constitutes a highly specialized microcirculation in which the permeability characteristics of the capillary wall allow its unique filtration function. The proliferation of MCs, an increase of mesangial lECM and detachment podocyte from GBM are key biological features of progressive glomerulonephritis (GN), leading to glomerular scarring and dysfunction. Thus, the study of the molecular and cellular mechanisms responsible for pathological glomerular alterations may help to elucidate the pathogenesis of progressive glomerular diseases. A growing body of evidence indicates that β1integrinfamily (β1 integrins), that mainly mediates cell adhesion to ECM, controls cell behaviors such as cell migration, proliferation, apoptosis and ECM assembly. In addition, a correlation between glomerular expression of β1 integrins and their ligand ECM components is observed in various human and experimental GN, suggesting that altered β1 integrins-mediated cell behaviors may contribute to the progression of GN. It is now becoming apparent that the expression of glomerular β1 integrins is not only critical for maintaining the glomerular capillary permeability but it modulates cell signaling pathways regulating the cell phenotypes involved in the progression of glomerular diseases.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
51
1-2
開始ページ
1
終了ページ
13
並び順
1
発行日
2004-02
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系