髙田, 信二郎 Department of Orthopedics, Institute of Health Biosciences,The University of Tokushima Graduate School
柴田, 瑩 Faculty of Pharmaceutical Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
米津, 浩 Department of Orthopedic Surgery, Shikoku Chuo Hospital
ヤマダ, トシヒデ Formulation Research Institute, Otsuka Pharmaceutical Co., Ltd.
高橋, 光彦 Department of Orthopedics, Institute of Health Biosciences,The University of Tokushima Graduate School KAKEN研究者をさがす
Abbaspour, Aziz Department of Orthopedics, Institute of Health Biosciences,The University of Tokushima Graduate School
Fourier transform infrared spectroscopy
phosphorus-31 solid-state nuclear magnetic resonance spectroscopy
peripheral quantitative computed tomography
In this review, we focus on findings obtained with biophysic techniques, Fourier transformed infrared (FTIR) spectroscopy and phosphorus-31 solid-state nuclear magnetic resonance (31P solid-state NMR) spectroscopy, which may allow us to evaluate bone quality and to predict bone strength. FTIR measures the absorption energy that produces an increase in the vibrational or rotational energy of atoms or groups of atoms within the molecule. FTIR spectroscopy allows us to examine the relative amount of minerals and matrix content and the arrangement of apatite and organic matrix. FTIR spectroscopy should become an important tool, because the relative amount of minerals and the arrangement of apatite and organic matrix could be a measure for evaluating bone quality. 31P solid-state NMR spectroscopy is useful for evaluating the quality of bone and predicting bone strength by calculating the spine-lattice relaxation time (T1) of bone. 31Psolid-stateNMRimaging can be used to measure quantitatively the mass of hydroxyapatite. The T1 relaxation time of both bone and deficient hydroxyapatite was much longer than that of pure hydroxyapatite. T1 relaxation time is one of the promising indices of bone quality.
The journal of medical investigation : JMI
jmi_51_3-4_133.pdf 543 KB