アクセス数 : ?
ダウンロード数 : ?
ID 110735
著者
オオタニ, ナオコ Division of Protein Information, Institute for Genome Research, The University of Tokushima
ヤマコシ, キミ Division of Protein Information, Institute for Genome Research, The University of Tokushima
高橋, 暁子 Division of Protein Information, Institute for Genome Research, The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ハラ, エイジ Division of Protein Information, Institute for Genome Research, The University of Tokushima
キーワード
cellular senescence
cell cycle control
tumor suppression
p16INK4a
資料タイプ
学術雑誌論文
抄録
The p16INK4a tumor suppressor protein functions as an inhibitor ofCDK4andCDK6, the D-type cyclin-dependent kinases that initiate the phosphorylation of the retinoblastoma tumor suppressor protein, RB. Thus, p16INK4a has the capacity to arrest cells in the G1-phase of the cell cycle and its probable physiological role is in the implementation of irreversible growth arrest termed cellular senescence. Cellular senescence is a state of permanent growth arrest that can be induced by a variety of stresses such as DNA-damage and aberrant mitogenic signaling in human primary cells. In contrast to normal cells, the function of the p16INK4a gene or its downstream mediators is frequently deregulated in many types of human cancers, illustrating the importance of cellular senescence in tumor suppression. Here we discuss the molecular mechanisms that direct cellular senescence and reveal its potential for tumor suppression.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
51
3-4
開始ページ
146
終了ページ
153
並び順
146
発行日
2004-08
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
総合教育センター