酒井, 徹 Department of International Public Health Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School|Department of Clinical Nutrition, Osaka Prefecture University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
コギソ, マリ Department of International Public Health Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School
ミツヤ, カオリ Department of International Public Health Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School
コマツ, タツシ Department of Clinical Nutrition, Osaka Prefecture University
The NC/Nga mouse is a model animal for human atopic dermatitis. In this study, we investigated oral tolerance induction in NC/Nga mice. In BALB/c mice, oral administration of ovalbumin (OVA) resulted in suppression of both OVA-specific T and B cell responses induced by OVA immunization. In NC/Nga mice, OVA-induced antigen (Ag) -specific T and B cell responses were significantly less than those in BALB/c mice. Furthermore, oral administration of OVA did not suppress OVA-specific immunoresponses in NC/Nga mice. We further examined antibody (Ab) response against food Ag by feeding mice an experimental diet that contained OVA or casein as a protein source. The level of serum OVA or casein-specific IgG was significantly higher in NC/Nga mice than in BALB/c mice. These results indicate that NC/Nga mice have a defect in the induction of oral tolerance. NC/Nga mice can therefore be used as a model for investigating the mechanism of oral tolerance.
The journal of medical investigation : JMI
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