ID 110790
著者
Alizadeh, Mohammad Department of Preventive Environment and Nutrition, Institute of Health Biosciences. The University of Tokushima Graduate School
太田, 房雄 Department of Preventive Environment and Nutrition, Institute of Health Biosciences. The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
細井, 和雄 Department of Molecular Oral Physiology, Institute of Health Biosciences. The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
カトウ, マコト Department of International Public Health Nutrition, Institute of Health Biosciences. The University of Tokushima Graduate School
酒井, 徹 Department of International Public Health Nutrition, Institute of Health Biosciences. The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Satter, Mohammed A. Institute of Food Science and Technology, Room No.1, BCSIR
キーワード
BPA
food allergy
OVA
IgE
IgG2a
cytokines
資料タイプ
学術雑誌論文
抄録
The Objective of this study was to elucidate if Bisphenol A (BPA) administration modulates T helper (Th) cell component of immune responses in a mouse challenged with ovalbumin (OVA), a major food antigen. BALB/c mice, (6 weeks old, female) were orally given either OVA (OVA-fed) or water (Water-fed), immunized intraperitoneally with OVA and injected with either BPA in corn oil or the vehicle alone. After subsequent 2nd immunization, serum titers of total IgE, OVA-specific IgE, IgG, IgG1 IgG2a and ability of their splenocytes for production of interferon (IFN)-γ, interleukin(IL) -4andIL-12 were examined by ELISA. Lymphocyte proliferation assay against concanavalin A (ConA) or OVA was also performed for 3H-Thymidine incorporation. In Water-fed groups, treatment with BPA resulted in lower titers of total IgE(P<0.01) and higher levels IgG2a (P<0.05) followed by a higher IFN-γ (P<0.05) and IL-12 (P<0.05) with an intact IL-4. When OVA-fed groups were examined, the compound did not change production of total and OVA-specific IgE and -IgG2a but resulted in lower production of IFN-γ (P<0.05). Also, BPA resulted in impaired lymphocyte proliferation to Con A in Water-fed groups (P<0.05) but not in tolerated animals. The findings indicate that BPA results in augmentation of Th1 immune responses but no significant effect on an established tolerance to OVA.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
53
1-2
開始ページ
70
終了ページ
80
並び順
70
発行日
2006-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
歯学系