アクセス数 : ?
ダウンロード数 : ?
ID 110876
著者
高山, 哲治 Department of Gastroenterology and Oncology, Institutes of Health Bioscience, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
郷司, 敬洋 Department of Gastroenterology and Oncology, Institutes of Health Bioscience, the University of Tokushima Graduate School KAKEN研究者をさがす
谷口, 達哉 Department of Gastroenterology and Oncology, Institutes of Health Bioscience, the University of Tokushima Graduate School
イノウエ, アツシ Department of Gastroenterology and Oncology, Institutes of Health Bioscience, the University of Tokushima Graduate School
キーワード
colorectal cancer
chemoprevention
aberrant crypt foci
資料タイプ
学術雑誌論文
抄録
Colorectal cancer is a leading cause of cancer-related mortality worldwide. Therefore, an appropriate prevention strategy should be urgently established. Chemoprevention involves the use of oral agents to suppress the development of cancer. Recent progress in the molecular analysis of colorectal cancer has revealed many candidate molecules for chemoprevention. Many new agents targeting these molecules have also been developed. These agents are largely classified into three categories : 1) Signal transduction modulators including epidermal growth factor (EGF) receptor inhibitors, anti-vascular endothelial growth factor (VEGF) antibodies, and inhibitors of oncogene products. 2) Epigenetic modulators including peroxisome proliferative activated receptor (PPAR)-γ agonists, estrogen receptor (ER)-β , and histone deacetylase inhibitors. 3) Anti-inflammatory modulators including cyclooxygenase (COX)-2, EP 1-4, and NF-kB. Of these agents, some actually proceeded to human clinical trials, and have been shown to be active chemopreventive agents.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
56
1-2
開始ページ
1
終了ページ
5
並び順
1
発行日
2009-02
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院