Gresik, Edward W City University of New York
Koyama, Noriko Asahi University
Hayashi, Toru Asahi University
Kashimata, Masanori Asahi University
Branching morphogenesis (BrM) is a basic developmental process for the formation of the lung, kidney, and all exocrine glands, including the salivary glands. This process proceeds as follows. An epithelial downgrowth invaginates into underlying mesenchyme, and forms a cleft at its distal end, which is the site of dichotomous branching and elongation ; this process of clefting and elongation is repeated many times at the distal ends of the invading epithelium until the desired final extent of branching is reached. The distal ends of the epithelium differentiate into the secretory endpieces, and the elongated segments become the ducts. This presentation is a brief historical review of studies on BrM during the development of the submandibular gland (SMG).
The Journal of Medical Investigation
Faculty of Medicine Tokushima University
jmi_56_suppl_228.pdf 105 KB