ID 111340
著者
Purwanti, Nunuk The University of Tokushima|Gadjah Mada University
Azlina, Ahmad The University of Tokushima
Karabasil, Mileva R The University of Tokushima|Belgrade University
キーワード
submandibular gland
IL-6
STAT3
duct-ligation
資料タイプ
学術雑誌論文
抄録
Ligation of the main excretory duct (MED) of the mouse submandibular gland (SMG) induced the expression of Sca-1, a stem cell marker. Sca-1 expression increased prominently in almost all of cells in the duct system, except the acinar cells. Sca-1 induction was accompanied with phosphorylated-STAT3 (Y705) elevation, which was localized in the nuclei of all duct cells. Electrophoretic mobility shift assay (EMSA) confirmed the specific binding of STAT3 to the GAS sequence, a biding site of gamma interferon activating site. Present study suggested one of the initial steps of the tissue regeneration after injury includes STAT3 pathway.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
56
Supplement
開始ページ
253
終了ページ
254
並び順
253
発行日
2009-12
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
生物資源系