ID 111343
著者
Satoh, Keitaro Dokkyo Medical University|Nihon University
Narita, Takanori Nihon University
Matsui-Inohara, Hikaru National Institute of Infectious Diseases
Ito, Tatsuro National Institute of Infectious Diseases
Senpuku, Hidenobu National Institute of Infectious Diseases
Sugiya, Hiroshi Nihon University
キーワード
dry mouth
saliva
pilocarpine
polyposia
Sjögren’s syndrome
資料タイプ
学術雑誌論文
抄録
Saliva contains a wide variety of secretory proteins, including α-amylase, lysozyme, peroxidase, immunoglobulins, and mucins. Hyposecretion of saliva and consequent dry mouth will lead to severe dental caries, periodontal disease, and mucosal infections, resulting in degrade of quality of life. Polyposia development is one of sign usually seen in dry mouth patients. However, little is reported in dry mouth-model animal regarding the entire process of polyposia development. We investigated the behavior of polyposia in E2F1-deficient non-obese diabetic/severe combined immunodeficiency disease (NOD/SCID) mice, as a dry mouth-model. E2F1-deficient NOD/SCID mice secreted small amount of saliva under the stimulation with a cholinergic agonist, pilocarpine, compared with control mice. The frequency of water intake by E2F-1-deficient NOD/SCID mice was more than that by control mice. These results suggest that E2F-1-deficient NOD/SCID mice show a behavior similar to polyposia and are very useful experimental model of dry mouth patients.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
56
Supplement
開始ページ
260
終了ページ
261
並び順
260
発行日
2009-12
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版