ID 111351
著者
Narita, Takanori Nihon University
Qi, Bing Nihon University
Fukano, Mika Nihon University
Matsuki-Fukushima, Miwako Nihon University
Murakami, Masataka National Institute for Physiological Sciences
Sugiya, Hiroshi Nihon University
キーワード
neurokinin A
salivary fluid secretion
submandibular gland
資料タイプ
学術雑誌論文
抄録
Neurokinin A (NKA) evokes salivary secretion. Despite such reports, the direct effect of NKA on salivary secreteion in submandibular gland has not been clarified. Here we studied characterization of salivary fluid secretion induced by NKA in the perfused submandibular grand (SMG) of the rat. NKA (3-100 nM) stimulated salivary fluid secretion in a dose-dependent manner. The profile of secretion induced by NKA consisted of two phases, transient and sustained phases. When the gland was perfused with Lucifer yellow (LY)-containing perfusate buffer and stimulated by NKA, concentration of LY in saliva was increased. In the absence of Ca2+ in the perfusate, NKA induced only a transient salivary fluid and a transient LY secretion. When the gland was treated with BAPTA, NKA failed to induce both salivary fluid secretion and LY secretion. These results suggest that NKA induces salivary secretion via both transcellular and paracellular pathways, which depends on intracellular Ca2+ mobilization.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
56
Supplement
開始ページ
278
終了ページ
280
並び順
278
発行日
2009-12
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版