Gee, Heon Yung Yonsei University College of Medicine
Park, Hyun Woo Yonsei University College of Medicine
Kim, Kyung Hwan Yonsei University College of Medicine
Lee, Min Goo Yonsei University College of Medicine
Polarized protein deposition at the apical and basolateral membranes of epithelial cells is critical for the asymmetrical transport of ions and fluids across the epithelia. PDZ-based modular adaptor proteins are expressed in the junctional areas in epithelial cells and are generally part of a molecular scaffold that determines the localization and activity of ion channels, receptors, and other signaling molecules to their correct spatial arrangement for proper response to diverse stimuli. Hence, understanding the regulatory mechanisms of channels and receptors via PDZ-based adaptors will provide valuable insights into the physiology of epithelial cells as well as pathophysiology of many human diseases including cystic fibrosis.
The Journal of Medical Investigation
Faculty of Medicine Tokushima University
jmi_56_suppl_302.pdf 154 KB