ID 111363
著者
Ko, Shigeru BH Nagoya University
Mizuno, Nobumasa Aichi Cancer Center Hospital
Yatabe, Yasushi Aichi Cancer Center Hospital
Yoshikawa, Toshiyuki Nagoya University
Ishiguro, Hiroshi Nagoya University
Yamamoto, Akiko Nagoya University
Azuma, Sakiko Nagoya University
Naruse, Satoru Nagoya University
Yamao, Kenji Aichi Cancer Center Hospital
Muallem, Shmuel UT Southwestern Medical Center
Goto, Hidemi Nagoya University
キーワード
Aquaporin1
autoimmune pancreatitis
immunolocalization
pancreatic exocrine function
secretin test
資料タイプ
学術雑誌論文
抄録
Chronic pancreatitis with all kinds of etiologies is characterized by pancreatic exocrine dysfunction especially impaired fluid secretion from pancreatic ducts. However, the molecular mechanism of this impaired fluid secretion in chronic pancreatitis is largely unknown. Aquaporin water channels are intrinsic membrane proteins expressed most of the cell types which have high osmotic water permeability. Among them aquaporin 1 (AQP1) is a predominant water channel expressed in the plasma membranes of human pancreatic ducts. Exocrine function test revealed that fluid secretion was severely impaired in AIP. immunohistochemical analysis revealed that AQP1 is localized mainly in the apical and lateral membranes of small pancreatic ducts in control subjects. AQP1 expression was significantly increased in plasma membranes of pancreatic ducts in AIP. Upregulation of AQP1 expression seen in pancreatic ducts of patient with AIP may be caused by the reduced fluid secretion from the pancreas as compensation. Further study would be required to elucidate the precise molecular mechanism for the role of AQP1 in pancreatic fluid secretion from the pancreas in diseases characterized by the impaired ductal fluid secretion such as cystic fibrosis.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
56
Supplement
開始ページ
318
終了ページ
321
並び順
318
発行日
2009-12
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版