ID 111371
著者
Yamaguchi, Makoto Nagoya University
Ishiguro, Hiroshi Nagoya University
Steward, Martin University of Manchester
Sohma, Yoshiro Keio University
Yamamoto, Akiko Nagoya University
Shimouchi, Akito National Cardiovascular Center Research Institute
Kondo, Takaharu Nagoya University
キーワード
pancreatic duct cell
mathematical model
SLC26A6
Cl--HCO3- exchanger
資料タイプ
学術雑誌論文
抄録
Pancreatic duct cells secrete a HCO3--rich (~140 mM) fluid. Using a computer model of the pancreatic duct, Sohma, et al. have demonstrated that the activity of a Cl-/ HCO3- exchanger with a 1 : 1 stoichiometry at the apical membrane would have to be suppressed in order to achieve such a HCO3--rich secretion. Recently the apical exchanger in pancreatic ducts has been identified as SLC26A6 and this probably mediates most of Cl--dependent HCO3- secretion across the apical membrane. SLC26A6 is reported to mediate electrogenic Cl-/2HCO3- exchange when expressed in Xenopus oocytes. To assess the implications of this 1 : 2 stoichiometry for HCO3- secretion, we have reconstructed the Sohma model using MATLAB/Simulink. To do this we have formulated an expression for the turnover rate of Cl-/2HCO3- exchange using network thermodynamics and we have estimated the constants from published experimental data. Preliminary data suggest that the 1 : 2 stoichiometry of SLC26A6 would favor HCO3- secretion at higher concentrations.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
56
Supplement
開始ページ
325
終了ページ
328
並び順
325
発行日
2009-12
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版