ID 111457
著者
Kim, Dusik University of Manchester
Steward, Martin C University of Manchester
キーワード
epithelial transport
exocrine secretion
exocrine glands
cystic fibrosis
資料タイプ
学術雑誌論文
抄録
The secretory epithelia of the pancreatic duct and airway share the ability to generate HCO3--rich fluids. They both express CFTR (cystic fibrosis transmembrane conductance regulator) at the apical membrane and both are adversely affected by cystic fibrosis. CFTR is predominantly a Cl- channel, and it is widely believed that HCO3- secretion in the pancreatic duct is mediated mainly by a Cl-/HCO3- exchanger at the apical membrane. Studies on airway epithelia, however, have suggested that CFTR, despite its low permeability to HCO3-, may nonetheless be directly responsible for HCO3- secretion across the apical membrane. This article reviews recent work that has re-examined both of these hypotheses.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
56
Supplement
開始ページ
336
終了ページ
342
並び順
336
発行日
2009-12
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版