Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice

Teshigawara, Kiyoshi; Hosaka, Toshio; Yamaguchi, Miwa; Terada, Eri; Kisyuku, Yuka; Fukunaga, Keiko; Hirata, Yohko; Jambaldorj, Bayasgalan; Harada, Nagakatsu; Sakai, Tohru; Nakaya, Yutaka

doi:10.2152/jmi.57.224

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ID	79137
著者	テシガワラ, キヨシ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School\|Division of Biofunctional Evaluation Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama 保坂, 利男 Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 山口, 美輪 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがすテラダ, エリ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School キシュク, ユカ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School フクナガ, ケイコ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School ヒラタ, ヨウコ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School Jambaldorj, Bayasgalan Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School 原田, 永勝 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす酒井, 徹 Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学教育研究者総覧 KAKEN研究者をさがす中屋, 豊 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学教育研究者総覧 KAKEN研究者をさがす
キーワード	HBA hyperlipidemia TNFα MCP1
資料タイプ	学術雑誌論文
抄録	Hyperbaric air (HBA) is used to improve healing of wounds including diabetic ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPARα and PGC-1α genes, which are related to lipid metabolism, were significantly up-regulated in the muscle and liver. Increases in TNFα and MCP1 mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes mellitus.
掲載誌名	The journal of medical investigation : JMI
ISSN	13431420
cat書誌ID	AA11166929
巻	57
号	3-4
開始ページ	224
終了ページ	231
並び順	224
発行日	2010-08
備考	The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID	265536
出版社版DOI	10.2152/jmi.57.224
出版社版URL	https://doi.org/10.2152/jmi.57.224
フルテキストファイル	LID201112132003.pdf 205 KB
言語	eng
部局	医学系