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ID 79153
著者
塩田, あすか Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
ハダ, タカヒコ Hada Giken, Co Ltd.
ババ, トモコ Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
サトウ, ミナコ Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
(山中)奥村, 仙示 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
山本, 浩範 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
竹谷, 豊 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
武田, 英二 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
glycoglycerolipid
5-Fluorouracil
mucositis
oxidative stress
資料タイプ
学術雑誌論文
抄録
Glycoglycerolipids are mostly found in plants, however the beneficial effects of
the glycoglycerolipids on mammalian body have not been understood. In this study, we
investigated the effects of glycolipid extracts from spinach, which highly contained glycoglycerolipids,
on mucosal injury induced by 5-fluorouracil (5-FU) in rats. Preadministration
of glycolipid extracts from spinach (20 mg/kg body weight) prevented villous atrophy,
misaligned crypts, and increased inflammatory cytokines in rat jejunum treated
with 5-FU (300 mg/kg body weight) compared with the extracts from soybean. The glycolipid
extracts from spinach highly contained monogalactosyl-diacylglycerol (MGDG)
and diglactosyl-diacylglycerol (DGDG). In Caco-2 cells, MGDG and DGDG inhibited the
production of reactive oxygen species induced by phorbol ester. We concluded that glycolipid
extracts from spinach has anti-oxidative and anti-inflammatory effects, and the
extract may be useful for prevention of drug-induced mucosal injury and other inflammatory
diseases.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
57
3-4
開始ページ
314
終了ページ
320
並び順
314
発行日
2010-08
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
フルテキストファイル
言語
eng
部局
医学系