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ID 79178
著者
タマガワ, カズヒコ Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School|Tomita Pharmaceutical Co. Ltd.
ナカヤマ イマオウジ, ハルユキ Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School
ワキモト, シン Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School
イチムラ, ミノル Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School
桑原, 知巳 Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School
キーワード
titanium oxide
inorganic phosphate
adsorbent
renal failure
資料タイプ
学術雑誌論文
抄録
Hyperphosphatemia adversely affects the prognosis of patients with chronic renal
failure (CRF). We synthesized a titanium oxide-like compound (TAP) as a phosphate
adsorbent for treatment of hyperphosphatemia in CFR patients. We evaluated the ability
of TAP to adsorb inorganic phosphate in vitro and in vivo. TAP was shown to contain
sulfate and hydroxyl groups by thermal analysis, which probably involved in phosphate
adsorption through an ionic exchange mechanism. TAP constantly adsorbed phosphate
(66.20-72.84 mg/g TAP) over a wide pH range (1.22-7.27) in vitro. To evaluate the phosphate
binding potential of TAP in vivo, adenine-induced CRF rats were fed AIN-76 diet
containing 3% TAP, 10% TAP, 3% sevelamer hydrochloride (clinical phosphate adsorbent),
or 3% calcium carbonate, and serum levels of phosphate and calcium and urinary phosphate
were compared with those in untreated CRF rats. Orally administered TAP showed
the inhibitory effect on serum phosphate level in adenine-induced CRF rats, which was
equivalent to that of sevelamer hydrochloride. These results indicate that TAP is a useful
alternative phosphate-binder with fewer side effects than sevelamer hydrochloride
and calcium carbonate.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
57
3-4
開始ページ
275
終了ページ
283
並び順
275
発行日
2010-08
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
フルテキストファイル
言語
eng