アクセス数 : ?
ダウンロード数 : ?
ID 83937
著者
シモハタ, タカアキ Department of Preventive Environment and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
髙橋, 章 Department of Preventive Environment and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
Vibrio parahaemolyticus
diarrhea
TDH
TRH
T3SS
資料タイプ
学術雑誌論文
抄録
Vibrio parahaemolyticus is a human pathogen that naturally inhabits marine
and estuarine environments. Infection with V. parahaemolyticus is often associated with
the consumption of raw or undercooked seafood, causing gastroenteritis with watery diarrhea.
The presence of two type III secretion system (T3SS) proteins, thermostable direct
hemolysin (TDH) and TDH-related hemolysin (TRH), has been closely associated with the
severity of diarrheal illness. TDH and TRH have various biological activities including
hemolytic activity, cardiotoxicity, and enterotoxicity. T3SS1 is involved in cytotoxicity
to host cells and orchestrates a multifaceted host cell infection by induction of autophagy,
cell rounding, and cell lysis. T3SS2 is thought to be related to the enterotoxicity
of V. parahaemolyticus. The activities of inducing diarrhea of each of the virulence factors
were summarized in this review.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
57
3-4
開始ページ
179
終了ページ
182
並び順
179
発行日
2010-08
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
フルテキストファイル
言語
eng
部局
医学系