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ダウンロード数 : ?
ID 83945
著者
キシモト, ミヤコ Department of Diabetes and Metabolic Medicine,National Center for Global Health and Medicine
エンドウ, ヒサコ Department of Diagnostic Pathology,National Center for Global Health and Medicine
ハギワラ, ショウタロウ Division of Hematology National Center for Global Health and Medicine
ミワ, アキヨシ Division of Hematology National Center for Global Health and Medicine
ノダ, ミツヒコ Department of Diabetes and Metabolic Medicine,National Center for Global Health and Medicine
キーワード
hemochromatosis
iron overload
pancreatic islets
diabetes
immunohistochemical analysis
資料タイプ
学術雑誌論文
抄録
Excessive iron storage sometimes causes diabetes in patients with hemochromatosis,
a disease caused by iron overloading. We performed an immunohistochemical
analysis to study an autopsy case of aplastic anemia and diabetic hemochromatosis caused
by frequent blood transfusions, and extensive hemosiderin deposition was observed in
the liver and pancreas. The pancreatic islets of the patient and a control subject were
stained to detect glucagon, insulin, and proinsulin. Significantly lower levels of immunoreactivity
with both insulin antibodies and proinsulin antibodies, but not with glucagon
antibodies, was observed in the islet cells in the patient’s tissue than in the islet cells of
the control. Hemosiderin deposition in the islets is known to be exclusively distributed
in the β-cells, thus, selective iron-induced damage to the β-cells may have affected insulin
synthesis and secretion and led to glucose intolerance in the patient.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
57
3-4
開始ページ
345
終了ページ
349
並び順
345
発行日
2010-08
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
フルテキストファイル
言語
eng