カスヤ, ヒデトシ Department of Neurosurgery, Tokyo Women’s Medical University
クボ, オサミ Department of Neurosurgery, Tokyo Women’s Medical University
カトウ, コウイチ Department of Neurosurgery, Tokyo Rosai Hospital
Krischek, Boris Department of Neurosurgery, University of Tübingen
Object. With the wider use of CT and MRI, many meningiomas are discovered as incidental findings during diagnostic work-up for unrelated symptoms. The majority shows no or minimal growth. The purpose of this study was to distinguish pathological features of incidentally-found growing meningiomas by comparing incidentally-found with symptomatic meningiomas. Methods. One hundred and thirty two consecutive nonrecurrent surgically-treated meningiomas treated between 2005 and 2007 were divided into three categories : 19 incidentally-found growing meningiomas (IG), 50 incidentallyfound meningiomas (I), and 63 symptomatic (S) meningiomas. The average follow-up period for the IG meningiomas was 3.7 years. Six out of 19 patients of the IG meningiomas became symptomatic during observation. Results. There is a significant difference of the incidence of WHO grades I, II, and III between all three groups (p=0.035). The incidence of WHO grades II and III in groups IG, I, and S were 26%, 2%, and 10%, respectively. We compare MIB-1 staining index between three groups : an average was 3.8% in IG, 1.3% in I, and 2.4% in S meningiomas. Conclusions. Incidentally-found meningiomas need careful follow-up. One fourth of the meningiomas that showed signs of growing belonged to the atypical or malignant grade.
The journal of medical investigation : JMI
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