アクセス数 : ?
ダウンロード数 : ?
ID 109577
著者
オカ, マキコ Department of Nutrition and Metabolism, the University of Tokushima Graduate School
ニワ, ヤスハル The Radiation Effects Research Foundation
馬渡, 一諭 Department of Nutrition and Metabolism, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
日浅, 芳一 The Tokushima Red Cross Hospital
中屋, 豊 Department of Nutrition and Metabolism, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
endothelin-1(1-31)
sandwich-ELISA
myocardial infarction
PTCA
資料タイプ
学術雑誌論文
抄録
Human chymase converts big endothelin (ET)-1 to 31-amino acid length ET-1 {ET-1(1-31)} that also possesses a potent vasoconstrictive action. In addition, ET-1(1-31) is an intermediate peptide, which is then readily transformed to mature ET-1 by the neutral endopeptidase 24-11. To investigate the relevance of pathophysiology of ET-1(1-31) in vivo, we have developed specific sandwich-type, enzyme-linked immunosorbent assay to measure the plasma concentration of ET-1(1-31) in healthy volunteers and patients with myocardial infarction. The plasma concentrations of ET-1(1-31) in healthy volunteers were 24.8±5.2 pg/ml (n=11). ET-1(1-31) concentration in plasma was elevated in patients with acute myocardial infarction, and its elevation was several times higher and lasted longer than that of ET-1. In addition, tissue concentration of ET-1(1-31) in the myocardium from a patient with acute myocardial infarction was extremely high (12729.8±2617.7 pg/mg protein). These results suggest that ET-1(1-31) may play some pathological roles in the remodeling, especially in sites where inflammatory cells produced a large amount of proteases, such as myocardial infarction.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
61
3-4
開始ページ
298
終了ページ
305
並び順
298
発行日
2014-08
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系