ID 111177
タイトル別表記
脳腫瘍における動脈スピンラベリング法及び多変量ダイナミック磁化率コントラスト灌流MRI法の比較
ASL and DSC MRI of brain tumors
著者
ハシバット, デルゲルダライ 徳島大学大学院医科学教育部(医学専攻)
Ganbold, Mungunbagana Tokushima University
宇山, 直人 Tokushima University
苛原, 早保 Tokushima University
キーワード
magnetic resonance imaging
arterial spin labeling
dynamic susceptibility contrast perfusion
time to maximum
brain tumor
資料タイプ
学位論文
抄録
Purpose : Arterial spin labeling (ASL) is an alternative method to Dynamic susceptibility contrast (DSC) perfusion MRI for brain tumors. However, ASL cerebral blood flow (CBF) can be easily affected by transit time. DSC MRI derived time to maximum of the residue function (Tmax) is possible to assess the transit time on ASL. Methods : Thirty patients with brain tumors were studied using ASL and DSC MRI. The relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), Tmax, and mean transit time (MTT) were obtained from DSC MRI. The ratios of the parameters were analyzed. Results : ASL CBF ratio correlated with the DSC rCBF ratio (r=0.78, p<0.001) and rCBV ratio (r=0.74, p<0.001). There was a moderate correlation between ASL CBF ratio and Tmax ratio (r=-0.43, p<0.05) in brain tumors. Conclusions : ASL CBF strongly correlated with DSC rCBF and rCBV. In addition, a negative correlation was found between ASL CBF and Tmax in brain tumors, indicating that these parameters would be affected by transit time. This may explain why ASL CBF is different from DSC rCBF and rCBV. The decreased DSC Tmax value may suggest high vascularity in a tumor.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
63
3-4
開始ページ
175
終了ページ
181
並び順
175
発行日
2016-08
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201606101003.pdf
論文本文 : LID201609291002.pdf
本論文は,著者Delgerdalai Khashbatの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2956号
学位記番号
甲医第1289号
学位授与年月日
2016-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院