ID 111182
タイトル別表記
resting state functional MRIによる自閉性障害若年者におけるdefault mode networkの変化に関する検討
Alteration of default mode network in children with autism spectrum disorder
著者
船越, 康宏 徳島大学大学院保健科学教育部(保健学専攻)
Iwanaga, Takashi University of Tokushima
キーワード
default mode network
resting state MRI
autism spectrum disorder
interior parietal lobule
posterior cingulate cortex
development
資料タイプ
学位論文
抄録
Purpose : The purpose of this study was to investigate changes in the functional connectivity of the default mode network (DMN) in normal aging and in children with autistic spectrum disorder (ASD) by using resting-state functional magnetic resonance imaging (rsfMRI) and independent component analysis. Methods : Thirty-one healthy controls (HC) in four age groups (1-3, 4-8, 20-29, and 50-59 years) and 14 childhood ASD cases (1-8 years of age) were examined by rsfMRI echo-planar imaging on a clinical 3-T MRI scanner. Imaging of all children (1-8 years) was conducted under sedation, while adults were scanned in the awake state with eyes closed. Results : The regions of DMN functional connectivity in the bilateral inferior parietal lobule and posterior cingulate cortex were smaller in HC children than in HC adults, and smaller in the ASD group than in the HC children. Conclusion : It is possible to observe developmental and pathological changes in the DMN by rsfMRI. Reduced DMN functional connectivity in children may be a useful biomarker for ASD diagnosis.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
63
3-4
開始ページ
204
終了ページ
208
並び順
204
発行日
2016-08
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨 : LID201701261003.pdf
審査要旨 : LID201701261004.pdf
論文本文 : LID201701261005.pdf
本論文は,著者Yasuhiro Funakoshiの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3004号
学位記番号
甲保第25号
学位授与年月日
2016-12-15
学位名
博士(保健学)
学位授与機関
徳島大学
部局
医学系