ID 111190
著者
Yukimasa, Nobuyasu Kagawa Prefectural University of Health Sciences
Sato, Shoichi Chiba Emergency Medical Center
Oboshi, Wataru Kagawa Prefectural University of Health Sciences
Watanabe, Toru Kagawa Prefectural University of Health Sciences
Uzawa, Ryuichi Uzawa Clinic
キーワード
hepatitis B vaccination
anti-HBs titers
cytokine gene polymorphisms
interleukin (IL)-10
tumor necrosis factor (TNF)-α
資料タイプ
学術雑誌論文
抄録
Hepatitis B (HB) vaccination is one of the most efficient tools to prevent the transmission of the virus. Considerable variability exists in HB vaccine responses, with 5-10% of healthy Japanese adults demonstrating no response following a standard vaccination. Recently, polymorphisms of immune-regulatory genes, such as cytokine genes, have been reported to influence the immune response to HB vaccine. The aim of this study was to investigate the underlying mechanisms of the genetic association between several cytokine gene polymorphisms and the immune response to HB vaccination in a Japanese population. One hundred and twenty three vaccinated young adults were classified according to the level of antibody-titer (anti-HBs). Single nucleotide polymorphism typing for IFN-γ(+874, 3’-UTR), IL-10 (−591, −819, −1082), and TNF-α(−308, −857), was accomplished using the PCR-RFLP or SSP-PCR method. The TNF-α(−857) CC type and the IL-10 (−1082) AG type were present more frequently in the low titer group than in the high titer group. The TNF-α(−857) CC type was found to be significantly associated with low response of serum anti-HBs. The anti-HBs antibody was not readily produced in the IL-10 (−1082) AG and TNF-α(−857) CC haplotype. Conversely, the antibody was readily produced in the IL-10 (−1082) AA and TNF-α(−857) CC haplotype, and the IL-10 (−1082) AA and TNF-α(−857) CT haplotype, suggesting a high likelihood of the IL-10 (−1082) AG type to be included in the low anti-HBs group, and high anti-HBs antibody production in those with the TNF-α(−857) CT type. These SNPs may produce ethnically-specific differences in the immune response to HB vaccine in the Japanese population.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
63
3-4
開始ページ
256
終了ページ
261
並び順
256
発行日
2016-08
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版