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ID 112232
タイトル別表記
ヤヌスキナーゼ阻害が体組成および糖代謝に与える影響
Effect of JAK inhibition on body composition
著者
筑後, 桃子 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
Sebe, Mayu Tokushima University
Iuchi, Marina Tokushima University
キーワード
Rheumatoid arthritis
Tofacitinib
Body composition
関節リウマチ
体組成
資料タイプ
学位論文
抄録
Tofacitinib is the first Janus Kinase (JAK) inhibitor to treat moderately to severely active RA. In this study, we investigated whether the effect of tofacitinib have any effects on body composition in mice and female patients with RA. Female C57BL/6 mice fed with a high-fat diet were treated with 30 mg/kg/day tofacitinib or vehicle for 70 days. Following treatment, trunk muscle, subcutaneous fat, and visceral fats were measured using X-ray computed tomography CT scan. Glucose tolerance and insulin sensitivity were assessed. In female RA patients treated with biological disease modified anti-rheumatic-drugs (biological DMARDs) or tofacitinib (n=4 per group), we also evaluated the body composition after 3 months from the start of treatment initiation using bioelectrical impedance analysis. Treatment with tofacitinib did not affect the body weight, and body composition in C57BL/6mice. It also did not affect glucose, and insulin tolerance in mice. In patients with RA, treatment with biological DMARDs did not affect the body composition whereas the muscle mass was unchanged after receiving tofacitinib and the fat mass was significantly increased.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA12022913
AA11166929
出版者
Faculty of Medicine Tokushima University
65
3-4
開始ページ
166
終了ページ
170
並び順
166
発行日
2018-08
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Momoko Chikugoの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3148号
学位記番号
甲栄第257号
学位授与年月日
2018-03-23
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系