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ID 116504
タイトル別表記
グルタミン酸ナトリウムの食事への添加は健常女性のT1R3味覚受容体遺伝子発現の増加に伴いタンパク質、塩分、糖分摂取などのバランスの取れた食事をもたらす
monosodium glutamate increases T1R3 expression
著者
Beppu, Kana Tokushima University
庄野, 仁志 徳島大学大学院医科学教育部(医学専攻)
Kawakami, Ayuka Tokushima University
Takashi, Tomoe Tokushima University
Watanabe, Suzuno Tokushima University
Yoshida, Akari Tokushima University
藤本, 知佐 Tokushima University
Ohnishi, Hiroki Tokushima University
キーワード
monosodium glutamate (MSG)
T1R3 genes
dietary balance
taste 1 receptor 3 (T1R3)
dysgeusia
資料タイプ
学位論文
抄録
We previously showed that chemotherapy-induced dysgeusia was associated with lingual taste receptor gene expression, and monosodium glutamate (MSG) improved dysgeusia by upregulating taste 1 receptor 3 (T1R3) gene expression. In recent years, decreased taste sensitivity has also been reported in some young people, and these are partly due to their disordered eating habits. From these background, we investigated the effects of MSG supplementation on taste receptor expression and dietary intake in healthy females. Fifteen young healthy volunteers were enrolled for the present crossover study and divided in two groups (dietary supplementation with MSG at 2.7 g / day or 0.27 g / day). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative PCR analysis. Food intake was assessed by food frequency questionnaire (FFQg), and body composition was measured using Omron HBF-701. T1R3 expression levels in the tongue and taste sensitivity increased significantly in participants who consumed <10 g of MSG daily, whereas no alteration was observed in participants who consumed >10 g of MSG daily. Furthermore, protein, fat, and carbohydrate (PFC) balance and salt and sugar intake improved by MSG supplementation. In conclusion, MSG supplementation increased T1R3 expression in the tongue and improved dietary balance.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
68
3-4
開始ページ
315
終了ページ
320
並び順
315
発行日
2021-08
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Hitoshi Shonoの学位論文として提出され,学位審査・授与の対象となっている。
著者名英表記誤記あり (誤)Takahito Azuma→(正)Takahiro Azuma
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3589号
学位記番号
甲医第1530号
学位授与年月日
2022-03-16
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院