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ID 117377
タイトル別表記
すべての胚移植に全胚凍結法が必要か。プロゲステロン上昇を伴わない新鮮胚移植は、凍結融解胚移植と同等の妊娠率をもたらす
A freeze-all strategy is not necessary for all embryo transfers
著者
阿部, 正美 徳島大学大学院医学研究科(医学専攻)
野口, 拓樹 Tokushima University
Tamura, Kou Tokushima University
Aoki, Hidenori Tokushima University
Takeda, Asuka Tokushima University
鎌田, 周平 Tokushima University
Tachibana, Ayaka Tokushima University
キーワード
freeze-all
fresh embryo transfer
progesterone level
資料タイプ
学位論文
抄録
Objectives : It has been suggested that the clinical outcomes of frozen-thawed embryo transfer (ET) are superior to those of fresh embryo transfer. We examined whether a freeze-all strategy is necessary for all embryo transfers, and, if not, to evaluate the conditions in which the pregnancy rates of fresh embryo transfer and frozen-thawed ET did not differ. Methods : Patients who underwent blastocyst transfer at Tokushima University Hospital between 2008 and 2019 were enrolled. The clinical outcomes and clinical characteristics of 1,022 patients that underwent fresh embryo transfer and 1,728 patients that underwent frozen-thawed ET were examined retrospectively. We considered the factors that influenced the pregnancy outcomes of fresh embryo transfer. Results : The frozen-thawed ET group exhibited significantly higher pregnancy, live-birth, and miscarriage rates than the fresh embryo transfer group. In the fresh embryo transfer group, a high progesterone level on the day of the human chorionic gonadotropin (hCG) trigger and lower grade embryos were risk factors for a low pregnancy rate. However, in the cases in which the progesterone level was < 1.0 ng / mL the pregnancy rate was equal to that of frozen-thawed ET. Conclusions : A freeze-all strategy is not necessary for embryo transfers, but should be employed in cases involving pre-ovulatory progesterone elevation.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
69
3-4
開始ページ
224
終了ページ
229
並び順
224
発行日
2022-08
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Masami Abeの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3645号
学位記番号
甲医第1538号
学位授与年月日
2022-07-28
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院