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ID 118283
タイトル別表記
Low dose RAI ablation
著者
Uno, Atsuhiko Osaka General Medical Center
Takeda, Hiroki Osaka General Medical Center
Mori, Masashi Osaka General Medical Center
Yamamoto, Yoshifumi Osaka General Medical Center
Takenaka, Yukinori Osaka General Medical Center|Osaka University
Enomoto, Keisuke Osaka General Medical Center|Wakayama Medical University
キーワード
radioactive iodine
papillary thyroid cancer
remnant ablation
1110 MBq (30 mCi)
thyroglobulin
資料タイプ
学術雑誌論文
抄録
Outpatient ablation therapy with low-dose radioactive iodine (RAI) is applied to non-low-risk papillary thyroid cancer patients due to a chronic shortage of inpatient RAI treatment wards in Japan. We used the maximum dosage available for outpatient therapy of 30 mCi of RAI for ablation and diagnostic (Dx) whole-body scintigraphy (WBS). This study aimed to examine the significance of the second dose of 30 mCi. DxWBS was performed 6 months after ablation, and assessment of success or failure was performed 12 months after ablation. A second WBS was performed in the remaining RAI accumulation cases in the neck on DxWBS. The criteria for successful ablation was negative cervical accumulation on WBS, thyroid stimulating hormone-suppressed thyroglobulin (sup-Tg) below 1.0 ng / mL, and no increase in thyroglobulin antibody (TgAb) level. At the time of DxWBS, 35 / 68 cases met the successful criteria, and 45 cases achieved success at assessment. Sup-Tg values decreased significantly after ablation and decreased further after DxWBS in successful ablation cases, whereas those were not changed in ablation failure cases. Findings indicated that RAI used in DxWBS had therapeutic effects. It makes sense to use 30 mCi for DxWBS, given the current difficulty of inpatient ablation therapy with high-dose RAI.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
70
1-2
開始ページ
17
終了ページ
21
並び順
17
発行日
2023-02
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系