ID | 118283 |
タイトル別表記 | Low dose RAI ablation
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著者 |
Uno, Atsuhiko
Osaka General Medical Center
Takeda, Hiroki
Osaka General Medical Center
Mori, Masashi
Osaka General Medical Center
Yamamoto, Yoshifumi
Osaka General Medical Center
Takenaka, Yukinori
Osaka General Medical Center|Osaka University
Enomoto, Keisuke
Osaka General Medical Center|Wakayama Medical University
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キーワード | radioactive iodine
papillary thyroid cancer
remnant ablation
1110 MBq (30 mCi)
thyroglobulin
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資料タイプ |
学術雑誌論文
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抄録 | Outpatient ablation therapy with low-dose radioactive iodine (RAI) is applied to non-low-risk papillary thyroid cancer patients due to a chronic shortage of inpatient RAI treatment wards in Japan. We used the maximum dosage available for outpatient therapy of 30 mCi of RAI for ablation and diagnostic (Dx) whole-body scintigraphy (WBS). This study aimed to examine the significance of the second dose of 30 mCi. DxWBS was performed 6 months after ablation, and assessment of success or failure was performed 12 months after ablation. A second WBS was performed in the remaining RAI accumulation cases in the neck on DxWBS. The criteria for successful ablation was negative cervical accumulation on WBS, thyroid stimulating hormone-suppressed thyroglobulin (sup-Tg) below 1.0 ng / mL, and no increase in thyroglobulin antibody (TgAb) level. At the time of DxWBS, 35 / 68 cases met the successful criteria, and 45 cases achieved success at assessment. Sup-Tg values decreased significantly after ablation and decreased further after DxWBS in successful ablation cases, whereas those were not changed in ablation failure cases. Findings indicated that RAI used in DxWBS had therapeutic effects. It makes sense to use 30 mCi for DxWBS, given the current difficulty of inpatient ablation therapy with high-dose RAI.
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掲載誌名 |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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cat書誌ID | AA11166929
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出版者 | Tokushima University Faculty of Medicine
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巻 | 70
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号 | 1-2
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開始ページ | 17
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終了ページ | 21
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並び順 | 17
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発行日 | 2023-02
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出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
医学系
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