ID 111004
著者
Fukunaga, Eri The University of Tokushima
Ohiwa, Yurie The University of Tokushima
Yamada, Mari The University of Tokushima
Sumi, Ayaka The University of Tokushima
キーワード
N,N-dimethyldodecylamine-N-oxide (DDAO)
cytotoxicity
lymphocyte
資料タイプ
紀要論文
抄録
N,N-Dimethyldodecylamine-N-oxide (DDAO) is an amphoteric surfactant used in many detergents for kitchens. In this study, the effects of DDAO (10–100 μM) on cell lethality, intracellular Ca2+ level, intracellular Zn2+ level, and cellular content of nonprotein thiol were examined in mammalian cells (rat thymocytes) to further characterize its cytotoxicity. DDAO at the concentration of 100 μM (22.9 mg/L) slightly, but significantly, increased the parameters described above, and it showed no significant effect at the concentrations of 30 μM (6.87 mg/L) or less. Therefore, it is unlikely that DDAO at environmentally-relevant concentrations (< 10–70 ng/L) exerts toxic actions on wild mammals and humans.
掲載誌名
自然科学研究
ISSN
09146385
cat書誌ID
AN10065859
29
1
開始ページ
1
終了ページ
4
並び順
1
発行日
2015-01
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
生物資源系