外来健診におけるメタボリックシンドロームとHbA１c5.4～5.7％の臨床的意義 : とくにhs-CRP とインスリン抵抗性について

To estimate of frequency of metabolic syndrome（MetS）in relatively aged mass examination（n=367）, 75gOGTT were particularly studied 76 out of 96 subjects to have been indicated levels of5.4～5.7%, moreover were compared to other clinical parameters. Frequency of MetS to be consideredmore than BS 110mg/dl were 4.5%, that’s of above HbA1c 5.5% were 31.5% in general mass.Because of OGTT there were recognized IGT about 1/2 of HbA1c 5.4%, 3/4 of 5.5～5.7% grouprespectively, that’s more was significantly increased HOMA-IR and decreased % FFA30 in HbA1c5.5～5.7%. The clinical characteristics of aged-MetS were obesity, low HDL-C/high TG, low adiponectin（Adipo.）/high Leptin, high IRI/FFA, elevated HOMA-IR, but not BS of OGTT. Thegroup of over HOMA-IR 1.7 were indicated waist obesity, low Adipo./high Lepin, high IRI/FFAand hypertension, and following relatively high hs-CRP（500ng/ml<）group were recognized lowHDL-C, high BS after OGTT, elevated IRI（120min）, FFA and high HOMA-IR but not the frequencyof MetS and hypertension. In comparison with both parameters and clinical examinationsthere were significant relationship on Leptin, F-IRI and FFA.From these results it was thought that participate the route of FFA-Macrophage and insulinresistance.