ビタミンＤ欠乏・不足高齢者への長期ビタミンＤ (1日, 1,000IU) 投与効果

Daily １，０００ IU vitamin D was supplemented to ８７ years old female（Case １）and ６８ years old male（Case ２）subjects with sarcopenia and vitamin D insufficiency／deficiency for ２ years and ５ months and ２ years and ７ months, respectively. Before, １ year and ９ months, and ２ years and ５ months after vitamin D supplementation in Case １, serum ２５‐hydroxyvitamin D［２５（OH）D］level was ９ ng/ml, ２３．８ ng/ml and ２３．１ ng/ml, skeletal muscle mass was ８．９５ kg, １０．２ kg and １０．０ kg, handgrip strength was ７．３ kg, ８．９ kg and ９．９ kg, and Barthel index was ４０, ８５ and ９０, respectively. Before, and ２ years and ７ months after vitamin D supplementation in Case ２, serum ２５（OH）D level was ２６ ng/ml and ３４．４ ng/ml, skeletal muscle mass was ２４．６ kg and ２５．１ kg, handgrip strength was ３７．２ kg and ３８．３ kg, and Barthel index was １００ and １００, respectively. Thus, activity of daily living（ADL）markedly improved in Case １ and keep high in Case ２. Therefore, it is suggested that daily １，０００ IU vitamin D supplementation is effective to keep QOL of aged persons higher.