動脈硬化から見た予防医学（アンチエイジングとウェルエイジング）

Although the average life span of the Japanese has lengthened to a great extent, health expectancy is very important issue for the promotion of public health. Management of vascular health can improve the health expectancy in subjects with lifestyle-related diseases including metabolic syndrome（MetS）. Since the development of atherosclerotic lesion formation is often found in patients with MetS, early detection of vascular dysfunction is essential to prevent cardiovascular diseases. We clinically use several medical equipment including ultrasound examination of carotid arteries, brachial-ankle pulse wave velocity（baPWV）, flow-mediated dilation（FMD）for non-invasive assessment of vascular function in patients with MetS. These vascular function analyses are very useful to plan and modify pharmacological intervention in each patient with MetS. In addition, diet therapy such as sodium restriction（less than６．０g／day）and exercise therapy with appropriate intensity are needed to maintain vascular function in patients with MetS.