ID | 111530 |
タイトル別表記 | Parathyroid cells : structure or Ca2+ sensing receptor
|
著者 |
斎藤, 史郎
徳島大学
|
キーワード | Ca2+ sensing receptor
Parathyroid
G protein coupled receptor
Familial hypocalciuric hypercalcemia
Autosomal dominant hypocalcemia
|
資料タイプ |
学術雑誌論文
|
抄録 | Using expression in Xenopus oocytes, Brown et al. cloned a bovine parathyroid Ca2+ sensing receptor (BoPCaRl). The 1,085 amino acid membrane protein is included in a class of putative seven transmembrane spanning structures that activate the phosphoinositol pathway through G proteins. Receptor activation presumably elevates intracellular Ca2+ to inhibit secretion of PTH. BoPCaRl has a big extracellular domain at the amino terminus. BoPCaRl is most similar to the metabotropic glutamate receptor. BoPCaRl mRNA is found in cells that have well known Ca2+ sensing function. Inheritance of one inactive Ca2+ sensing receptor gene causes familial hypocalciuric hypercalcemia (FHH) and autosomal dominant hypocalcemia. Mutations in the extracellular domain and in a portion of the third intracellular loop domain decrease the receptor’s sensitivity, causing FHH. Extracellular domain mutations increase the receptor’s activity at low Ca2+ concentration to cause autosomal familial hypocalcemia.
|
掲載誌名 |
日本臨牀
|
ISSN | 00471852
|
cat書誌ID | AN00198641
|
出版者 | 日本臨牀社
|
巻 | 53
|
号 | 4
|
開始ページ | 805
|
終了ページ | 810
|
発行日 | 1995-04
|
EDB ID | |
フルテキストファイル | |
言語 |
jpn
|
著者版フラグ |
出版社版
|
部局 |
歯学系
|