直近一年間の累計
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ID 118732
タイトル別表記
sdLDL-C and Cardiovascular Events
著者
Yamaji, Takayuki Hiroshima University
Harada, Takahiro Hiroshima University
Kajikawa, Masato Hiroshima University
Maruhashi, Tatsuya Hiroshima University
Kishimoto, Shinji Hiroshima University
Mohamad Yusoff, Farina Hiroshima University
Chayama, Kazuaki Hiroshima University
Goto, Chikara Hiroshima International University
Nakashima, Ayumu Hiroshima University
Tomiyama, Hirofumi Tokyo Medical University
Takase, Bonpei National Defense Medical College Research Institute
Kohro, Takahide Jichi Medical University
Suzuki, Toru University of Leicester
Ishizu, Tomoko University of Tsukuba
Ueda, Shinichiro University of the Ryukyu
Yamazaki, Tsutomu The University of Tokyo
Furumoto, Tomoo Hokkaido University
Kario, Kazuomi Jichi Medical University
Inoue, Teruo Dokkyo Medical University
Watanabe, Kentaro Yamagata University
Takemoto, Yasuhiko Osaka Metropolitan University
Hano, Takuzo Wakayama Medical University
Ishibashi, Yutaka Shimane University
Node, Koichi Saga University
Maemura, Koji Nagasaki University
Ohya, Yusuke University of the Ryukyus
Furukawa, Taiji Teikyo University
Ito, Hiroshi Okayama University
Yamashina, Akira Tokyo Medical University
Koba, Shinji Showa University
Higashi, Yukihito Hiroshima University
キーワード
Small dense low-density lipoprotein cholesterol
Triglycerides
Type 2 diabetes mellitus
Statin
Cardiovascular events
資料タイプ
学術雑誌論文
抄録
Aim: There is little information on the relationships of serum small dense low-density lipoprotein cholesterol (sdLDL-C) levels and serum triglyceride (TG) levels with cardiovascular events in patients with coronary artery disease (CAD) and type 2 diabetes mellitus (DM) who are receiving statins. The aim of this study was to evaluate the relationships of serum TG levels and sdLDL-C levels as residual risks for cardiovascular events in patients with CAD and type 2 DM who were being treated with statins.
Methods: The subjects were divided into four groups based on TG levels and sdLDL-C levels: sdLDL-C of <40.0 mg/dL and TG of <150 mg/dL, sdLDL-C of ≥ 40.0 mg/dL and TG of <150 mg/dL, sdLDL-C of <40.0 mg/dL and TG of ≥ 150 mg/dL, and sdLDL-C of ≥ 40.0 mg/dL and TG of ≥ 150 mg/dL. During a median follow-up period of 1419 days, cardiovascular events occurred in 34 patients.
Results: The incidences of cardiovascular events were significantly higher in patients with sdLDL-C of ≥ 40.0 mg/dL and TG of <150 mg/dL and in patients with sdLDL-C of ≥ 40.0 mg/dL and TG of ≥ 150 mg/dL, but not in patients with sdLDL-C of <40.0 mg/dL and TG of ≥ 150 mg/dL, than in patients with sdLDL-C of <40.0 mg/dL and TG of <150 mg/dL.
Conclusions: Under the condition of treatment with statins, patients with CAD and type 2 DM who had sdLDL-C levels of ≥ 40.0 mg/dL had a high risk for cardiovascular events even though serum TG levels were controlled at <150 mg/dL.
掲載誌名
Journal of Atherosclerosis and Thrombosis
ISSN
18803873
13403478
出版者
Japan Atherosclerosis Society
31
4
開始ページ
478
終了ページ
500
発行日
2024-04-01
権利情報
This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc-sa/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系