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ID 119421
著者
Hayashi, Junya Tokushima University
Kobayashi, Daishiro Tokushima University
資料タイプ
学術雑誌論文
抄録
Late-stage formation of a sactionine thioether bond connecting a Gly α-carbon and Cys thiol was achieved by Lossen rearrangement of a glycyl hydroxamic acid (GlyHA) residue in a peptide. Lossen rearrangement allowed conversion of GlyHA within a peptide to an N-acyl iminium equivalent, which subsequently reacted with S-acetamidomethyl Cys (Cys(Acm)) in TFA in the presence of guanidine hydrochloride (Gn·HCl) to yield the desired thioether linkage in the final stage.
掲載誌名
Organic Letters
ISSN
15237060
15237052
cat書誌ID
AA11347843
AA1218968X
出版者
ACS Publications
26
24
開始ページ
5167
終了ページ
5171
発行日
2024-06-07
備考
論文本文は2025-06-07以降公開予定
権利情報
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.4c01685.
EDB ID
出版社版DOI
出版社版URL
言語
eng
著者版フラグ
その他
部局
薬学系