健診集団におけるHOMA-IRとHOMA-ADの臨床的比較検討

Recently there were many reported to concern with insulin resistance, and then the relationship of HOMA-IR and HOMA-AD were studied, such as, the former was fasting plasma glucose （mg／dl）×fasting IRI（μU／ml）／４０５, the later was fasting plasma glucose×fasting IRI／adiponectin （μg／ml）in medical outpatients. The first group was tested ７５g OGTT（n＝７６）to have been indicted HbA１c５．４～５．７％（GTT group）out of ３６７ medical outpatients, the second group was１５９ （medical examination group）in３４６subjects. HbA１c levels of GTT group was５．５３±０．１２％, that of medical examination group was ５．４１±０．７３％, accordingly it was thought that the glucose intolerance in together group were almost equally. Therefore the relationship of the clinical parameters, such as age, obesity, the frequency of hypertension and dyslipidemia, the serum level of adiponectin（A）, leptin（L）, free fatty acid were alternately studied and there were slightly recognized significant difference to be concerned with obesity, HOMA-AD and the frequency above fasting blood glucose １１０mg／dl in both groups, but not other clinical parameters. On the relationships with the clinical examination parameters and HOMA-IR vs HOMA-AD, the significant correlation coefficient that were HDL-C, adiponectin, L／A and F-IRI were respectively admitted in GTT group, and the group of medical outpatients were obviously noticed waist circumference, FPG, F-IRI, adiponectin and L／A. Besides the correlations coefficient on each of HOMA-IR and HOMA-AD of GTT group and medical examination group were significantly estimated r＝＋０．７１４and r＝＋０．７５３respectively. From these results there were thought that HOMA-IR was related glucose intolerance, but HOMA-AD was participated fatty acid metabolism in GTT group. Another the medical examination groups were especially estimated metabolic syndrome parameters of both HOMA. It was reflected that the examinations of medical outpatients of both groups were concerned in the index of insulin resistance, such as fatty acid, lipid and glucose metabolism on HOMA-AD to be related adiponectin.