ID 110310
タイトルヨミ
ケンシン シュウダン ニオケル HOMA-IR ト HOMA-AD ノ リンショウテキ ヒカク ケントウ
タイトル別表記
Clinical study on the comparison of HOMA-IR and HOMA-AD in medical examinations of outpatients
著者
三谷, 裕昭 三谷内科
キーワード
HOMA-IR
HOMA-AD
insulin resistance
資料タイプ
学術雑誌論文
抄録
Recently there were many reported to concern with insulin resistance, and then the relationship of HOMA-IR and HOMA-AD were studied, such as, the former was fasting plasma glucose (mg/dl)×fasting IRI(μU/ml)/405, the later was fasting plasma glucose×fasting IRI/adiponectin (μg/ml)in medical outpatients. The first group was tested 75g OGTT(n=76)to have been indicted HbA1c5.4~5.7%(GTT group)out of 367 medical outpatients, the second group was159 (medical examination group)in346subjects. HbA1c levels of GTT group was5.53±0.12%, that of medical examination group was 5.41±0.73%, accordingly it was thought that the glucose intolerance in together group were almost equally. Therefore the relationship of the clinical parameters, such as age, obesity, the frequency of hypertension and dyslipidemia, the serum level of adiponectin(A), leptin(L), free fatty acid were alternately studied and there were slightly recognized significant difference to be concerned with obesity, HOMA-AD and the frequency above fasting blood glucose 110mg/dl in both groups, but not other clinical parameters. On the relationships with the clinical examination parameters and HOMA-IR vs HOMA-AD, the significant correlation coefficient that were HDL-C, adiponectin, L/A and F-IRI were respectively admitted in GTT group, and the group of medical outpatients were obviously noticed waist circumference, FPG, F-IRI, adiponectin and L/A. Besides the correlations coefficient on each of HOMA-IR and HOMA-AD of GTT group and medical examination group were significantly estimated r=+0.714and r=+0.753respectively. From these results there were thought that HOMA-IR was related glucose intolerance, but HOMA-AD was participated fatty acid metabolism in GTT group. Another the medical examination groups were especially estimated metabolic syndrome parameters of both HOMA. It was reflected that the examinations of medical outpatients of both groups were concerned in the index of insulin resistance, such as fatty acid, lipid and glucose metabolism on HOMA-AD to be related adiponectin.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
66
1-2
開始ページ
27
終了ページ
32
並び順
27
発行日
2010-04-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版