ID 110310
Title Transcription
ケンシン シュウダン ニオケル HOMA-IR ト HOMA-AD ノ リンショウテキ ヒカク ケントウ
Title Alternative
Clinical study on the comparison of HOMA-IR and HOMA-AD in medical examinations of outpatients
Author
Mitani, Hiroaki Mitani Clinic
Keywords
HOMA-IR
HOMA-AD
insulin resistance
Content Type
Journal Article
Description
Recently there were many reported to concern with insulin resistance, and then the relationship of HOMA-IR and HOMA-AD were studied, such as, the former was fasting plasma glucose (mg/dl)×fasting IRI(μU/ml)/405, the later was fasting plasma glucose×fasting IRI/adiponectin (μg/ml)in medical outpatients. The first group was tested 75g OGTT(n=76)to have been indicted HbA1c5.4~5.7%(GTT group)out of 367 medical outpatients, the second group was159 (medical examination group)in346subjects. HbA1c levels of GTT group was5.53±0.12%, that of medical examination group was 5.41±0.73%, accordingly it was thought that the glucose intolerance in together group were almost equally. Therefore the relationship of the clinical parameters, such as age, obesity, the frequency of hypertension and dyslipidemia, the serum level of adiponectin(A), leptin(L), free fatty acid were alternately studied and there were slightly recognized significant difference to be concerned with obesity, HOMA-AD and the frequency above fasting blood glucose 110mg/dl in both groups, but not other clinical parameters. On the relationships with the clinical examination parameters and HOMA-IR vs HOMA-AD, the significant correlation coefficient that were HDL-C, adiponectin, L/A and F-IRI were respectively admitted in GTT group, and the group of medical outpatients were obviously noticed waist circumference, FPG, F-IRI, adiponectin and L/A. Besides the correlations coefficient on each of HOMA-IR and HOMA-AD of GTT group and medical examination group were significantly estimated r=+0.714and r=+0.753respectively. From these results there were thought that HOMA-IR was related glucose intolerance, but HOMA-AD was participated fatty acid metabolism in GTT group. Another the medical examination groups were especially estimated metabolic syndrome parameters of both HOMA. It was reflected that the examinations of medical outpatients of both groups were concerned in the index of insulin resistance, such as fatty acid, lipid and glucose metabolism on HOMA-AD to be related adiponectin.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
66
Issue
1-2
Start Page
27
End Page
32
Sort Key
27
Published Date
2010-04-25
FullText File
language
jpn
TextVersion
Publisher