ID | 110710 |
Author |
Kajimoto, Kazuaki
Institute for Genome Research, The University of Tokushima
Yamazaki, Naoshi
Faculty of Pharmaceutical Sciences, The University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Kataoka, Masatoshi
Institute for Genome Research, The University of Tokushima
Terada, Hiroshi
Faculty of Pharmaceutical Sciences, Tokyo University of Science
Shinohara, Yasuo
Institute for Genome Research, The University of Tokushima|Faculty of Pharmaceutical Sciences, The University of Tokushima|Single-Molecule Bioanalysis Laboratory, National Institute of Advanced Industrial Science and Technology (AIST)
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
|
Keywords | brown adipose tissue
mitochondria
energy metabolism
uncoupling
|
Content Type |
Journal Article
|
Description | Brown adipose tissue (BAT) is believed to function by dissipating excess energy in mammals. It is very important to understand the energy metabolism held in BAT since disorder of its energy-dissipating function may cause obesity or lifestyle-related diseases such as hypertension and diabetes. This function in BAT is mainly attributable to uncoupling protein (UCP), specifically expressed in its mitochondria. This protein consumes excess energy as heat by dissipating the H+ gradient across the inner mitochondrial membrane that is utilized as a driving force for ATP synthesis. In this review article, in addition to providing a brief introduction to the functional properties of BAT and UCP, we also describe and discuss properties of cultured brown adipocytes and the results of our exploratory studies on protein components involved in the energy-dissipating function in BAT.
|
Journal Title |
The journal of medical investigation : JMI
|
ISSN | 13431420
|
NCID | AA11166929
|
Volume | 51
|
Issue | 1-2
|
Start Page | 20
|
End Page | 28
|
Sort Key | 20
|
Published Date | 2004-02
|
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
TextVersion |
Publisher
|
departments |
Pharmaceutical Sciences
Institute of Advanced Medical Sciences
|